The University of Luxembourg is looking within the Systems Biology group at the Life Sciences Research Unit (LSRU) of its Faculty of Science, Technology and Communication for a :
Postdoc in molecular cell biology / systems biology (M/F)
The University of Luxembourg offers the opportunity to apply for a post- doc research grant in Luxembourg. The grant is directly tied to the candidate. The candidate has to apply for the grant personally. In case of an accepted application, the position will be financed by the Luxemburgish AFR (Aide Formation Recherche) fellowship( further information and guidelines on http://www.afr.lu en/AFR-Grants-Activities/AFR-
• 2-year fixed term contract, beginning July 1st, 2012 at the earliest
• Employee status
The research of the Systems Biology group (Prof. Thomas Sauter) is focused in the area of molecular systems biology. We are developing and applying different modelling and data integration techniques to generate suitable computational models of biological systems and processes. We are also performing experimental validation of the models using cell cultivation facilities and molecular analytics. The analysis of these models helps to gain insight into dynamic and stationary properties of the investigated. These integrated approaches provide a more complete understanding of cellular and molecular responses observed during diseases and may lead to new therapeutic targets.
The hypereosinophilic syndrome (HES) is a myeloproliferative disorder marked by a sustained overproduction of eosinophils. It can be linked to the occurrence of the oncogenic fusion protein FIP1L1-PDGFRá in patient cohorts. Detection of this fusion gene detection has proven to be useful for clinical diagnosis. But to date, only preliminary biomarkers for HES have been suggested. Based on a well established set of wildtype and disease specific PDGFRá variants, we will therefore generate FIP1L1-PDGFRá specific data sets on the proteomic, transcriptomic and metabolomic level. The analysis will focus on the PDGFRá wildtype, the treatment-sensitive FIP1L1-PDGFRá, the therapy-resistant FIP1L1-PDGFRá D842V-mutant and a rich panel of YF-mutants with specific knockdowns of downstream signalling pathways. We will use this data to increase our understanding of the molecular effects of the oncogenic FIP1L1-PDGFRá and to screen for putative perturbation sensitive targets and disease bio!
markers for HES. A close interaction with a computational biologist performing mathematical model based network curation and target identification is required. Selected promising sensitive network points as well as oncongenic mechanisms of selected potential biomarkers will be validated and followed up experimentally.
Profile
• PhD in Biology/Biochemistry or equivalent.
• Experience in cell biology, proteomics, transcriptomics and / or metabolomics required.
• Good knowledge in English
• Additional French and/or German would be ideal
The University of Luxembourg is an equal opportunity employer.
Please send your motivation letter, CV, scanned diplomas and references files until January 8th, 2012 to:
Prof. Thomas Sauter (thomas.sauter@uni.lu)
Thank you for quoting job reference source, when applying.
The selected candidate will apply for the PhD grant scheme from the FNR (Fonds National de la Recherche) and the position will be filled under the condition that the grant is provided.
------------------------------
Delporte
beatrice.delporte@uni.lu
University of Luxembourg
Luxembourg
Ansprechpartner: Delporte
