Postdoc in Cellular Microbiology

“c-Abl signal transduction in Helicobacter pylori infected epithelial
 cells”

We are seeking a highly motivated and talented scientist in the field
 of cellular microbiology. In particular we are interested in the
 investigation of the molecular mechanism of how H. pylori promotes
 cellular survival and migration while preventing apoptosis. In our
 previous work, we identified a crucially important role of the non-
receptor tyrosine kinase c-Abl in H. pylori-infected gastric
 epithelial cells in these processes, but the molecular mechanisms of
 this novel cross-talk are still unknown. Since c-Abl already
 represents an attractive target molecule in drug intervention in
 certain neoplasia, increasing knowledge of c-Abl signaling obtained
 from this proposed project may also uncover novel strategies in
 therapeutic intervention of H. pylori-related diseases.

Recent publications: Oncogene, 2007, 26: 3462-3472; J Clin Invest,
 2012, 122: 1553-1566

Candidates:
•       should have a strong background in cell biology, and either
 expertise in infection biology, or in molecular aspects of signal
 transduction
•       are expected to be independent, scientific-orientated and self-
motivated
•       must have received their Ph.D. within the last five years with
 a proven publication record with at least one first author paper
•       have excellent communication and interpersonal skills
•       are competitive at international level
•       collaborate with internal and external collaborators and
 support other group members
•       Employ cutting-edge technologies and standard molecular
 biology tools in combination with infection biology to study kinase
 signaling during pathogen-host interaction

We hold a state-of-the art laboratory at the Paris-Lodron University
 of Salzburg in Austria, a beautiful place at the northern boundary of
 the Alps. The Department of Molecular Biology provides broad
 possibilities for interaction and support. Our group is a member of
 the international "PhD program ICA" (University of Salzburg/FWF) and
 a member of the priority program "Bioscience and Health" (University
 of Salzburg).

Please send your CV and letter of interest to Silja Wessler
 (silja.wessler@sbg.ac.at). The duration of the position is two years
 with the possibility of extension.

Closing date: August 20, 2012