Postdoc estudiando la relación entre genotipo y fenotipo en el Institute of Integrative Biology (ETH Zurich)

Oferta compartida por Nuria

The Computational Biology group in the Institute of Integrative Biology at ETH Zurich, led by Joshua L. Payne, is hiring a postdoctoral researcher with funding for up to two years. The group is broadly interested in evolution, particularly in the relationship between genotype and phenotype, and the role of mutation in the generation of adaptive phenotypic variation. We study these topics at multiple scales of information transmission from DNA to protein, with an emphasis on transcriptional regulation and translation. A predefined project centered around these topics is available, but we are also open to defining a project around the applicant's interests.

The group is currently made up of four PhD students and one postdoc. Interdisciplinarity is key to our research and this shows in our team composition, with backgrounds in physics, biophysics, computer science, developmental biology, and evolution. We value diversity - at present we represent four continents - and we strive to maintain a 50-50 gender balance. Applicants from underrepresented groups are especially encouraged to apply.

The successful candidate will have experience in some form of computational science, a passion for evolutionary biology, and a Ph.D. in a related discipline (math, physics, bioinformatics, computer science, life sciences). Fluency in a major programming language is essential, as is the ability to work both autonomously and cooperatively within an interdisciplinary, multicultural team. Experience modeling evolutionary processes or analyzing large-scale biological datasets, such as from functional genomics assays or massively parallel sequence-to-function assays, is a plus. We will begin considering applications immediately with the aim of a September 1st, 2021 start date. Later start dates are
also possible.

To be considered for the position, please send a single pdf file to joshua.payne@env.ethz.ch including your CV, publication list, a single-paged statement of research interests, and contact information for 2-3 academic references. Please write Postdoc2021 in the subject line.

Representative papers from the group:
Cano et al. (2021) "Mutation bias shapes the spectrum of adaptive substitutions." bioRxiv
Rozhonova & Payne (2021) "Little evidence the standard genetic code is optimized for resource conservation." bioRxiv
Majic & Payne (2020) "Enhancers facilitate the birth of de novo genes and gene integration into regulatory networks." Molecular Biology and Evolution, 37, 1165-1178.
Payne et al. (2019) "Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis." PLoS Biology, 17, e3000265.
Payne & Wagner (2019) $B!H (BThe causes of evolvability and their evolution. $B!I (B Nature Reviews Genetics, 20, 24-38.

Group website: joshualevipayne.com